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Related Experiment Videos

Cyclical progestogens for heavy menstrual bleeding.

A Lethaby1, G Irvine, I Cameron

  • 1University of Auckland, O&G FMHS, Grafton Rd, Private Bag 92019, Auckland, New Zealand 1142. a.lethaby@auckland.ac.nz

The Cochrane Database of Systematic Reviews
|February 7, 2008
PubMed
Summary
This summary is machine-generated.

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Oral progestogens are commonly prescribed for heavy menstrual bleeding (HMB). This review found that while a 21-day course reduces blood loss, it

Area of Science:

  • Gynecology
  • Pharmacology

Background:

  • Heavy menstrual bleeding (HMB) affects many women, often without anatomical pathology.
  • Medical therapy is preferred over surgery for HMB management.
  • Oral progestogens are frequently prescribed for HMB.

Purpose of the Study:

  • To evaluate oral progestogen effectiveness for reducing menstrual blood loss in women with HMB.
  • To compare luteal phase vs. 21-day progestogen regimens.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs).
  • Searched Cochrane, MEDLINE, and EMBASE databases.
  • Included women with regular heavy periods and no pathological causes.

Main Results:

  • No placebo-controlled trials found.

Related Experiment Videos

  • Luteal phase progestogens were less effective than tranexamic acid, danazol, and IUS.
  • 21-day progestogen regimen reduced blood loss but was less acceptable than IUS.

    • Conclusions:

    • Progestogens (days 15/19-26) offer no advantage over other treatments for menorrhagia.
    • A 21-day progestogen regimen effectively reduces menstrual blood loss.
    • This regimen may be suitable for short-term menorrhagia treatment.