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[Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp]
Congzhe Tian1, Yanli Tan, Yongping Gao
1Department of Otolaryngology, Affiliated Hospital of Hebei University, Baoding, 071000, China. yongyong5752@vip.sina.com
Objective:
To study the effect of IgE, GM-CSF on eosinophil accumulation in the nasal polyps and find the relationship between them.
Method:
Thirty mucosa constitution samples of nasal polyps and eleven inferior nasal concha were observed. The distribution of IgE was detected by SP immunohistochemical method, while the concentration of GM-CSF was measured by ELISA technique and the number of eosinophils were counted in the same tissues.
Result:
The level of IgE, GM-CSF and eosinophils had significant different between the nasal polyps and control group (P < 0.01). There was positive correlation between IgE/GM-CSF and the number of eosinophils in the nasal polyps group (r = 0.65, 0.62, P < 0.01). The correlation between concentration of IgE and GM-CSF was also significant in nasal polyps group (r = 0.52, P < 0.01).
Conclusion:
Nasal polyps is characterized by eosinophil accumulation. IgE and GM-CSF may contribute to the recruitment of eosinophils in nasal polyps. Type-I allergy mediated by IgE play an important role in the pathogenesis of nasal polyps.
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