Aggregation behavior of nucleoside-boron cluster conjugates in aqueous solutions
Pavel Matejícek1, Petr Cígler, Agnieszka B Olejniczak
1Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 43 Prague 2, Czech Republic.
Langmuir : the ACS Journal of Surfaces and Colloids
|February 9, 2008
Summary
Boron-containing nucleoside conjugates show aggregation in water, influenced by cluster properties. This behavior can be predicted and aids in designing boronated drugs for cancer therapy and antiviral applications.
Area of Science:
- Supramolecular Chemistry
- Nanotechnology
- Medicinal Chemistry
Background:
- Nucleoside conjugates are crucial in drug design.
- Boron clusters offer unique properties for therapeutic applications.
- Understanding self-assembly is key for developing novel drug delivery systems.
Purpose of the Study:
- To investigate the aggregation behavior of boron-containing nucleoside conjugates in aqueous solutions.
- To determine the influence of boron cluster characteristics on self-assembly.
- To establish a correlation between aggregation tendency and physicochemical properties.
Main Methods:
- Light scattering measurements to detect aggregation.
- Atomic force microscopy to visualize nanoparticle formation.
- Partition coefficient measurements in water-octanol systems.
Main Results:
- Boron-containing nucleoside conjugates exhibit aggregation in water.
- Aggregation is dependent on the size, charge, and structure of the boron cluster.
- Specific boron clusters form stable nanoparticles, while others and unmodified nucleosides do not.
- Aggregated species interact with nonionic surfactants like Triton X-100.
- Partition coefficients correlate with aggregation tendency.
Conclusions:
- The self-assembly of boron-containing nucleoside conjugates is predictable based on cluster properties.
- This aggregation behavior is relevant for designing boronated nucleosides for Boron Neutron Capture Therapy (BNCT) and antiviral drugs.
- Findings contribute to understanding biological properties and optimizing drug design.
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