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Ontogenetic Sequence Analysis: using parsimony to characterize developmental sequences and sequence polymorphism.

Matthew W Colbert1, Timothy Rowe

  • 1University of Texas High-Resolution X-ray CT Facility, Jackson School of Geosciences, University of Texas at Austin, Austin, Texas 78712, USA. colbert@mail.utexas.edu

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
|February 9, 2008
PubMed
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Ontogenetic Sequence Analysis (OSA) reveals developmental patterns and variability within species. This method maps complex, reticulating networks, advancing evolutionary biology research.

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Ontogenetic sequences are crucial for biological comparisons, but variability within species is often overlooked.
  • Traditional analyses assume largely invariant developmental sequences, potentially missing significant biological insights.

Purpose of the Study:

  • To introduce a novel method, Ontogenetic Sequence Analysis (OSA), for mapping and quantifying variability in developmental sequences.
  • To formalize hierarchical developmental patterns and enable robust intra- and interspecific comparisons.

Main Methods:

  • Utilizes parsimony algorithms to construct reticulating networks representing developmental sequence variability.
  • Applies the OSA method to human postnatal skeletal ossification data, including hand/wrist epiphyseal unions and wrist ossification.

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Main Results:

  • OSA successfully generates formalized diagrams of reticulating networks, illustrating most parsimonious developmental sequences.
  • Demonstrates the method's validity in discovering sequence patterns and predicting unobserved morphologies.
  • Provides a framework for developing statistics to compare intraspecific and interspecific sequence variation.

Conclusions:

  • Ontogenetic Sequence Analysis offers a powerful approach to incorporate developmental sequence variability into evolutionary studies.
  • Highlights the prevalence and importance of sequence polymorphism in development.
  • OSA advances the integration of morphological data into evolutionary analyses by accounting for developmental plasticity.