Related Experiment Video
Updated: Jul 7, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Clinica use of platelet additive solutions
1Sanquin Blood Bank South West Region, Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands. d.vanrhenen@sanquin.nl
Randomized clinical trials for new platelet products are limited. This review discusses recent trials, advocating for their use before clinical application to ensure safety and efficacy.
Area of Science:
- Hematology
- Transfusion Medicine
- Clinical Research
Background:
- Limited randomized clinical trials (RCTs) exist for novel platelet products utilizing platelet additive solutions.
- Ensuring the clinical efficacy and safety of these new transfusion products is crucial.
Purpose of the Study:
- To review recent randomized clinical trials concerning new platelet products.
- To highlight the importance of RCTs in the development pathway of transfusion products.
Main Methods:
- Discussion of recently published randomized clinical trials.
- Literature review of studies on platelet additive solutions and their clinical application.
Main Results:
- A scarcity of recent randomized clinical trials (RCTs) was identified for new platelet products.
- The reviewed RCTs provide a foundation for future product evaluation.
Conclusions:
- Randomized clinical trials are essential before the widespread clinical adoption of new platelet products.
- This review signifies a potential shift towards rigorous RCT evaluation prior to clinical practice implementation.
Related Concept Videos
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

