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EANM procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy

Francesco Giammarile1, Arturo Chiti, Michael Lassmann

  • 1CH Lyon Sud, EA 3738, HCL, UCBL, 165 Chemin du Grand Revoyet, 69495, Pierre Benite Cedex, France. francesco.giammarile@chu-lyon.fr

European Journal of Nuclear Medicine and Molecular Imaging
|February 16, 2008
PubMed

Meta-iodobenzylguanidine, or Iobenguane, is an aralkylguanidine resulting from the combination of the benzyl group of bretylium and the guanidine group of guanethidine (an adrenergic neurone blocker). It is a noradrenaline (norepinephrine) analogue and so-called "false" neurotransmitter. This radiopharmaceutical, labeled with 131I, could be used as a radiotherapeutic metabolic agent in neuroectodermal tumours, that are derived from the primitive neural crest which develops to form the sympathetic nervous system. The neuroendocrine system is derived from a family of cells originating in the neural crest, characterized by an ability to incorporate amine precursors with subsequent decarboxylation. The purpose of this guideline is to assist nuclear medicine practitioners to evaluate patients who might be candidates for 131I-meta-iodobenzylguanidine to treat neuro-ectodermal tumours, to provide information for performing this treatment and to understand and evaluate the consequences of therapy.

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