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Compaction behavior of roller compacted ibuprofen.

Sarsvatkumar Patel¹, Aditya Mohan Kaushal, Arvind Kumar Bansal

¹Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research, SAS. Nagar, India.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|February 19, 2008

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Lower roller compaction pressure enhances ibuprofen granule tabletability and densification. This study reveals how compaction pressure impacts particle properties, crucial for pharmaceutical manufacturing.

Area of Science:

Pharmaceutical Technology
Materials Science
Chemical Engineering

Background:

Roller compaction is a key granulation method in pharmaceutical manufacturing.
Understanding granule properties is vital for tablet quality and performance.

Purpose of the Study:

To investigate the impact of roller compaction pressure on ibuprofen granule properties.
To analyze the effects on bulk compaction, densification, and tabletability.

Main Methods:

Utilized an instrumented rotary tablet press with three different roller pressures.
Performed Heckel analysis, Walker analysis, compressibility, and tabletability tests.
Measured nominal single granule fracture strength using micro tensile testing.

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Main Results:

Lower roller pressure resulted in lower granule yield strength.
Higher roller pressure reduced tabletability, aligning with granule size enlargement theory.
Lower pressure granules exhibited higher bonding strength due to fines and fragmentation.

Conclusions:

Granules produced with lower roller compaction pressure demonstrated superior tabletability and densification.
Roller compaction pressure significantly influences particle-level properties like specific surface area and fracture strength.
Optimizing compaction pressure is crucial for controlling ibuprofen granule characteristics and subsequent tablet performance.