Related Experiment Videos
Effects of thymoxamine on corneal endothelium
K Green1, J M Chapman, L Cheeks
1Department of Ophthalmology, Medical College of Georgia, Augusta 30912-3400.
Lens and Eye Toxicity Research
|January 1, 1991
Abstract:
We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.