Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Losing B cell identity.

Sebastian Carotta1, Stephen L Nutt

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 23, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining the rules of engagement: B cells, antibodies and cancer control.

Cellular & molecular immunology·2026
Same author

Interleukin 4 selectively expands functional type 1 conventional dendritic cells from bone marrow progenitors.

Cell reports·2025
Same author

Flicking the switch for B-cell development.

Genes & development·2025
Same author

Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.

Nature immunology·2025
Same author

Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models.

Cell reports. Medicine·2025
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

The transcription factor Pax5 is crucial for B cell development and identity. Loss of Pax5 in mature B cells can lead to de-differentiation and is linked to B cell malignancies and leukemia.

Area of Science:

  • Immunology
  • Molecular Biology
  • Developmental Biology

Background:

  • The transcription factor Pax5 is a key regulator in the development of B cells from hematopoietic progenitors.
  • Pax5 plays a critical role in establishing and maintaining B cell lineage commitment.
  • Recent findings indicate Pax5's continuous requirement throughout B cell development, not just initial commitment.

Purpose of the Study:

  • To investigate the role of Pax5 in reinforcing B cell commitment throughout development.
  • To understand the consequences of Pax5 inactivation in mature B cells.
  • To explore the link between Pax5 function, B cell identity, and associated malignancies.

Main Methods:

  • Inactivation of the Pax5 gene in mature B cells.
  • Analysis of B cell de-differentiation and multi-lineage potential.

Related Experiment Videos

  • Examination of B cell malignancies in mouse models.
  • Review of human PAX5 mutations in acute lymphoblastic leukemia.

    • Main Results:

    • Inactivation of Pax5 in mature B cells leads to de-differentiation to a progenitor-like state.
    • These de-differentiated cells exhibit multi-lineage potential.
    • Loss of Pax5 function is associated with B cell malignancies in mouse models.
    • PAX5 mutations are a common genetic lesion in human acute lymphoblastic leukemia.

    Conclusions:

    • Pax5 is essential not only for initial B cell commitment but also for maintaining B cell identity throughout development.
    • The continuous function of Pax5 is critical for preventing de-differentiation and maintaining B cell lineage.
    • Disruption of Pax5 function has significant implications for B cell development and is strongly linked to B cell cancers.