Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

Secondary Spinal Cord Injury llI: Pathophysiology

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neurologic running injuries.

Physical medicine and rehabilitation clinics of North America·2008

Same author

Gender differences exist in neuromuscular control patterns during the pre-contact and early stance phase of an unanticipated side-cut and cross-cut maneuver in 15-18 years old adolescent soccer players.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2008

Same author

Neuromuscular and lower limb biomechanical differences exist between male and female elite adolescent soccer players during an unanticipated side-cut maneuver.

The American journal of sports medicine·2007

Same author

Neuromuscular and lower limb biomechanical differences exist between male and female elite adolescent soccer players during an unanticipated run and crosscut maneuver.

The American journal of sports medicine·2007

Same author

Gender differences exist in osteoarthritic gait.

Clinical biomechanics (Bristol, Avon)·2007

Same author

Knee biomechanics of moderate OA patients measured during gait at a self-selected and fast walking speed.

Journal of biomechanics·2006

Same journal

Sports Neurology.

Neurologic clinics·2026

Same journal

Sports-Related Peripheral Nerve Injuries.

Neurologic clinics·2026

Same journal

Active Rehabilitation and Return to Play in Sports-Related Concussion.

Neurologic clinics·2026

Same journal

Autonomic Assessment and Management in Sports-Related Concussion.

Neurologic clinics·2026

Same journal

Management of Vestibular Symptoms in Sports-Related Concussion.

Neurologic clinics·2026

Same journal

Neuropsychological Assessment in Sport-Related Concussion: Evidence, Controversies, and Clinical Applications.

Neurologic clinics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

Neurologic running injuries.

Kelly A McKean¹

¹Nike Sports Research Laboratory, One Bowerman Drive, Mia Hamm 1, Beaverton, OR 97005, USA. kelly.mckean@nike.com <kelly.mckean@nike.com>

Neurologic Clinics

|February 26, 2008

Summary

This summary is machine-generated.

Neurologic running injuries are often misdiagnosed. This review covers nerve injuries in runners, including etiology, symptoms, diagnosis, and treatment, to help differentiate them from common musculoskeletal issues.

More Related Videos

Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury

Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury

Published on: July 31, 2021

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

Published on: October 6, 2020

Related Experiment Videos

Last Updated: Jul 7, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury

Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury

Published on: July 31, 2021

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

Published on: October 6, 2020

Area of Science:

Sports Medicine
Neurology
Running Biomechanics

Background:

Neurologic running injuries represent a small but potentially underdiagnosed category of athletic ailments.
Commonly reported nerve involvements in runners include the interdigital, tibial, peroneal, and sural nerves.

Purpose of the Study:

To review the etiology, symptoms, diagnosis, and treatment of specific neurologic running injuries.
To provide guidance for differentiating nerve injuries from more prevalent musculoskeletal running injuries.

Main Methods:

Literature review of reported neurologic running injuries.
Comparative analysis of nerve injury versus musculoskeletal injury characteristics.

Main Results:

Neurologic injuries may be underdiagnosed in the running population.
Specific nerve injuries (interdigital, tibial, peroneal, sural) present distinct clinical pictures.

Conclusions:

Accurate diagnosis of neurologic running injuries is crucial for appropriate management.
Understanding the differences between nerve and musculoskeletal injuries aids in effective differential diagnosis and treatment planning.