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Amnestic mild cognitive impairment: structural MR imaging findings predictive of conversion to Alzheimer disease

G Karas1, J Sluimer, R Goekoop

  • 1Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, the Netherlands. GB.Karas@vumc.nl

AJNR. American Journal of Neuroradiology
|February 26, 2008
PubMed
Abstract

Insights

Structural brain differences in mild cognitive impairment (MCI) can predict Alzheimer

Area of Science:

  • Neuroimaging
  • Neurology
  • Alzheimer's Disease Research

Background:

  • Mild cognitive impairment (MCI) is often considered a preclinical stage of Alzheimer's disease (AD).
  • Identifying early indicators of AD progression in MCI patients is crucial for timely intervention.

Purpose of the Study:

  • To investigate whether structural brain differences detected by MRI can predict the conversion of amnestic MCI to AD.
  • To explore the utility of voxel-based morphometry (VBM) in identifying early AD-related brain changes.

Main Methods:

  • Twenty-four patients with amnestic MCI underwent baseline 1.5T MRI scans.
  • Voxel-based morphometry (VBM) was used to assess localized gray matter volume differences.
  • Patients were followed for 3 years to determine conversion to AD.

Main Results:

  • 46% of MCI patients progressed to AD within 3 years.
  • Patients who converted to AD showed reduced gray matter volume in medial and lateral temporal lobes, and parietal lobes.
  • Statistically significant left-sided atrophy in the parietal and lateral temporal lobes predicted conversion.

Conclusions:

  • Brain atrophy beyond the medial temporal lobe is characteristic of MCI patients who will develop dementia.
  • Atrophy in the left lateral temporal lobe and left parietal cortex may serve as independent predictors of MCI conversion to AD.

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