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Updated: Jul 7, 2026
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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Aneurysm pulsatility after endovascular exclusion--an experimental study using human aortic aneurysms.
Hussein Amin Orra1, Pedro Puech-Leão, Erasmo Simão da Silva
1Cirurgia Vascular e Endovascular, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Clinics (Sao Paulo, Brazil)
|February 26, 2008
Summary
Endograft repair of human aneurysms shows transmitted pulsation to the aneurysm wall, even without endoleak. This pulsation should not be mistaken for a sign of procedural failure.
Area of Science:
- Vascular Surgery
- Biomedical Engineering
- Medical Device Technology
Background:
- Aneurysm pulsatility is a key factor in disease progression and rupture risk.
- Endovascular aneurysm repair (EVAR) aims to exclude the aneurysm from circulation.
- Assessing residual pulsatility after EVAR is crucial for evaluating treatment efficacy.
Purpose of the Study:
- To quantify the pulsatility of human aortic aneurysms before and after endograft exclusion.
- To determine if endograft implantation reduces aneurysm wall pulsation.
- To investigate the significance of transmitted pulsation in the context of endoleak absence.
Main Methods:
- Necropsy-derived human aortic aneurysm specimens were used.
- A pulsatile perfusion system simulated physiological conditions.
- Volume dislocation via saline column displacement measured pulsatility before and after endograft implantation.
- Mural thrombus was preserved, and the device was secured in place.
Main Results:
- Aneurysm pulsatility, measured by saline column amplitude, decreased after endograft insertion in all specimens.
- Observed reductions in pulsatility ranged from 3.5 cm to 23 cm.
- All endografts were correctly positioned and attached, with no detected endoleaks.
Conclusions:
- Endograft pulsation is transmitted to the aneurysm wall even when endoleaks are absent.
- Transmitted pulsation does not necessarily indicate a failed repair.
- Further research may be needed to understand the long-term implications of transmitted pulsation.
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