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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Biomimetic hydroxyapatite particulate nanofiber modified silicon: in vitro bioactivity
Santosh Aryal1, Madhab Prasad Bajgai, Myung Seob Khil
1Center for Healthcare Technology Development, Chonbuk National University, Jeonju, Republic of Korea.
Journal of Biomedical Materials Research. Part A
|February 29, 2008
Summary
Researchers developed a novel nanofibrous hydroxyapatite (HA) material mimicking bone for silicon wafer modification. This biocompatible composite shows promise for bone implant applications, enhancing cell growth and integration.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Materials Engineering
Background:
- Hydroxyapatite (HA) is a key component of bone mineral.
- Developing HA-based materials that mimic bone matrix is crucial for bone regeneration.
- Surface modification of materials like silicon wafers can improve biocompatibility.
Purpose of the Study:
- To create a novel particulate nanofibrous hydroxyapatite (HA) material.
- To functionalize silicon wafers with HA using electrospinning for potential bone implant applications.
- To evaluate the crystallographic purity, microstructure, biocompatibility, and cell interaction of the developed HA material.
Main Methods:
- Electrospinning of HA precursors in a viscous polymer solution.
- Controlled calcination of electrospun nanofibers.
- Powder X-ray diffraction (XRD) for crystallographic analysis.
- Atomic Force Microscopy (AFM) and Field Emission Scanning Electron Microscopy (FE-SEM) for microstructure and morphology analysis.
- AFM for surface roughness and adhesion force measurements.
Main Results:
- Successful fabrication of particulate nanofibrous HA mimicking bone matrix.
- XRD analysis confirmed crystallographic purity of HA, with a temperature-dependent reflection at the (300) HA plane.
- FE-SEM and AFM revealed a microstructure promoting cell spreading and penetration, not aggregation.
- Surface roughness and adhesion force were quantified using AFM.
Conclusions:
- The developed nanofibrous HA material is crystallographically pure and biocompatible.
- The material's morphology supports favorable cell-material interactions, essential for bone implants.
- This HA composite matrix demonstrates significant potential for use as a bone implant material.
