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Related Experiment Video

Updated: Jul 7, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Lower extremity amputation: a contemporary series.

Patrick A Stone1, Sarah K Flaherty, J David Hayes

  • 1Vascular Surgery Division, West Virginia University, Charleston Division, USA.

The West Virginia Medical Journal
|March 4, 2008
PubMed
Summary
This summary is machine-generated.

Lower extremity amputations in a nonurban population showed high perioperative mortality and limited survival, particularly with more proximal amputations. Early vascular intervention may improve outcomes and reduce amputation levels.

Related Experiment Videos

Last Updated: Jul 7, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Area of Science:

  • Vascular Surgery
  • Orthopedic Surgery
  • Rehabilitation Medicine

Background:

  • Lower extremity amputations are often performed on high-risk patients.
  • Outcomes vary based on surgeon discipline and patient population.
  • Understanding amputation results is crucial for improving patient care.

Purpose of the Study:

  • To analyze outcomes of non-traumatic lower extremity amputations.
  • To compare results across different amputation levels and surgical disciplines.
  • To identify factors influencing mortality, morbidity, and functional recovery.

Main Methods:

  • Retrospective review of 411 patients undergoing 508 amputations.
  • Data collected from January 1999 to December 2003.
  • Analysis included amputation level, perioperative mortality, stump failure, morbidity, and survival rates.

Main Results:

  • Below-knee amputation was most frequent (50.9%).
  • 30-day mortality was 11%, increasing with proximal amputation levels.
  • Stump failure rates were significant (34.5% for transmetatarsal, 12% for below-knee).
  • 29% experienced non-wound related morbidity.
  • Only 27% of those with available rehabilitation data ambulated with a prosthesis.
  • 2-year survival was only 23%.

Conclusions:

  • Major lower extremity amputations indicate high-risk surgical patients.
  • Significant perioperative morbidity and poor survival are characteristic of this cohort.
  • Early vascular surgery referral may decrease proximal amputations and enhance functional outcomes.