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Four-alpha-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analyses

Dejian Ma1, Nicole R Brandon, Tanxing Cui

  • 1Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15260, USA.

Biophysical Journal
|March 4, 2008
PubMed
Summary

This study reveals the high-resolution structure of a designed four-alpha-helix bundle, a mimic for general anesthetic binding sites. The structure elucidates specific anesthetic-protein interactions crucial for understanding anesthesia mechanisms.

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