[Pulmonary sequestration in Iceland - two case reports]

Area of Science:

• Pulmonology
• Developmental Biology
• Medical Case Reports

Background:

• Pulmonary sequestration (PS) is a rare congenital lung malformation characterized by non-functioning lung tissue.
• Its vascular supply typically arises from aberrant systemic arteries, distinct from the normal bronchopulmonary tree.
• The precise etiology of PS remains incompletely understood, with ongoing debate regarding congenital versus acquired origins.

Observation:

• This report details two distinct cases of pulmonary sequestration diagnosed in Iceland.
• These cases present unique clinical and anatomical features relevant to PS etiology.
• This marks the first documented instances of PS within the Icelandic population.

Findings:

• The presented cases provide novel evidence supporting the hypothesis that pulmonary sequestration is a congenital malformation.
• Observations align with a developmental etiology, suggesting PS arises during embryonic development.
• The findings challenge theories proposing acquired origins for this condition.

Implications:

• These findings contribute to a refined understanding of the pathogenesis of pulmonary sequestration.
• The study reinforces the classification of PS as a congenital anomaly.
• This research may inform future diagnostic and potentially therapeutic strategies for patients with PS.