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Dual-mode surface-plasmon-resonance sensors using angular interrogation.

Jing Guo1, P Donald Keathley, J T Hastings

  • 1Department of Electrical and Computer Engineering, University of Kentucky, Lexington, KY 40506, USA. jguo3@uky.edu

Optics Letters
|March 4, 2008
PubMed
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This study introduces angular interrogation for dual-mode surface-plasmon-resonance (SPR) sensors. This new method significantly improves the ability to distinguish between surface binding and bulk changes in sensing applications.

Area of Science:

  • Analytical Chemistry
  • Biophysics
  • Materials Science

Background:

  • Surface-plasmon-resonance (SPR) sensors are crucial for detecting biological, chemical, medical, and environmental analytes.
  • Existing dual-mode SPR sensors differentiate surface binding from bulk refractive index changes.
  • Improved methods are needed to enhance this differentiation for more accurate sensing.

Purpose of the Study:

  • To present a novel angular interrogation approach for dual-mode SPR sensing.
  • To enhance the differentiation between surface binding events and bulk index variations.
  • To improve the cross-sensitivity performance of SPR sensors.

Main Methods:

  • Excitation of both long- and short-range surface plasmons simultaneously.
  • Utilizing angular interrogation at a single sensing location and wavelength.

Related Experiment Videos

  • Comparing angular interrogation with traditional wavelength-interrogated dual-mode SPR sensors.

    • Main Results:

    • The proposed angular interrogation method enables simultaneous excitation of two surface-plasmon modes.
    • Demonstrated at least a 3.6-fold improvement in surface and bulk cross-sensitivity.
    • Achieved better differentiation between surface and bulk effects compared to existing methods.

    Conclusions:

    • Angular interrogation offers a superior approach for dual-mode SPR sensing.
    • This technique significantly reduces cross-sensitivity, leading to more reliable measurements.
    • The findings advance the capabilities of SPR sensors in various analytical applications.