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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Risk factors and mortality in patients with nosocomial Staphylococcus aureus bacteremia

Fu-Der Wang1, Yin-Yin Chen, Te-Li Chen

  • 1Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. fdwang@vghtpe.gov.tw

American Journal of Infection Control
|March 4, 2008
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia significantly increases mortality risk compared to methicillin-susceptible S aureus (MSSA). Identifying risk factors like CVC use is crucial for managing these infections.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) infections are a growing global healthcare concern.
  • Staphylococcus aureus bacteremia remains a significant cause of hospital-acquired infections.

Purpose of the Study:

  • To evaluate the clinical significance, specifically mortality, of MRSA versus methicillin-susceptible S aureus (MSSA) bacteremia.
  • To identify independent risk and prognostic factors for mortality in S aureus bacteremia.

Main Methods:

  • Retrospective cohort study analyzing 1148 cases of nosocomial S aureus bacteremia over 15 years.
  • Logistic regression and survival analyses were employed to assess mortality risk factors.

Main Results:

  • MRSA bacteremia was associated with a significantly higher mortality rate (49.8%) compared to MSSA bacteremia (27.6%).
  • Logistic regression revealed MRSA bacteremia mortality to be 1.78 times higher than MSSA (P < .001).
  • Independent risk factors for MRSA included service type, prior admission days, age, mechanical ventilation, and central venous catheter (CVC) use.

Conclusions:

  • Methicillin resistance is a critical independent prognostic factor in S aureus bacteremia.
  • Factors such as advanced age, neoplasms, prolonged hospitalization, mechanical ventilation, and CVC use also predict poorer outcomes.

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