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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Vaccinations01:51

Vaccinations

Overview
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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Related Experiment Video

Updated: Jul 7, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Immunization and dermatophytes.

Bernard Mignon1, Jérémy Tabart, Aline Baldo

  • 1Department of Infectious and Parasitic Diseases, Parasitology, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. bmignon@ulg.ac.be

Current Opinion in Infectious Diseases
|March 5, 2008
PubMed
Summary
This summary is machine-generated.

Developing effective vaccines for dermatophytosis (fungal skin infections) in animals and humans requires further research. Recent advances in understanding host-dermatophyte interactions and virulence factors are key to improving current vaccination strategies.

Related Experiment Videos

Last Updated: Jul 7, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Area of Science:

  • Medical Mycology
  • Immunology
  • Veterinary Dermatology

Background:

  • Dermatophytosis remains a prevalent fungal disease in both animals and humans.
  • Current vaccines for dermatophytosis have limitations, necessitating further development.

Purpose of the Study:

  • To provide an update on the current understanding of host-dermatophyte interactions.
  • To highlight recent advances relevant to developing improved dermatophytosis vaccines.

Main Methods:

  • Review of recent scientific literature on dermatophytosis.
  • Focus on molecular characterization of dermatophytic virulence factors.
  • Analysis of host immune responses to dermatophyte infections.

Main Results:

  • Identification and molecular characterization of key dermatophytic virulence factors, such as secreted proteases.
  • Detailed studies on the roles of these factors in infection and immunopathogenesis.
  • Increased documentation of host immune responses, including innate immunity.
  • Availability of new molecular tools to accelerate dermatophyte research.

Conclusions:

  • Enhanced knowledge of host-dermatophyte relationships is crucial.
  • This knowledge will inform the development of effective and safe dermatophytosis vaccines.
  • Future strategies will benefit from molecular insights into virulence and host immunity.