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Updated: Jul 6, 2026

Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis
Published on: October 19, 2021
[Developmental peculiarities of gas transporting system in chick embryo under respiratory surface restriction]
Abstract:
The half of the chick eggshell surface was covered by the gas-proof layer on the 11th day and the incubation was continued up to the 14th day. The histological investigation of the chorioallantoic membrane after three days of experiment revealed that the blood vessels reduction in the covered part was completely compensated for by vessel dilatation and the growing in the mesodermal layer of intact part with parallel reorganization and dilation of capillary network on its surface. The blood gas capacity increase was supported for by haematocrit and haemoglobin growth and erythropoiesis stimulation. Cardiac work intensification was provided with the left ventricular myocyte hyperplasia and accelerated differentiation. The coordinated mobilization of all branches of gas transporting system compensated for surface half diminution to maintain the normal metabolic level in embryo during 11-14th days of incubation.
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