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Related Concept Videos

The Mitotic Spindle02:27

The Mitotic Spindle

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...
The Mitotic Spindle02:27

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The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
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Related Experiment Video

Updated: Jul 6, 2026

Multichannel Extracellular Recording in Freely Moving Mice
08:59

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Published on: May 26, 2023

Midline spikes.

T Yong1, S Chayasirisobhon, J S Yoshina

  • 1Neruodiagnostics Laboratory and Epilepsy Center, Department of Neurology, Kaiser Permanente Medical Center, Anaheim, California 92807, USA.

Clinical EEG and Neuroscience
|March 6, 2008
PubMed
Summary
This summary is machine-generated.

Midline spikes, a rare EEG finding (0.21%), are often seen in children with seizures. Their origin may stem from generalized thalamocortical networks or focal parasagittal cortical activity.

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Area of Science:

  • Neurology
  • Clinical Neurophysiology
  • Epileptology

Background:

  • Interictal midline spikes are specific electroencephalogram (EEG) findings.
  • Their occurrence is infrequent, necessitating further investigation into their clinical significance.

Purpose of the Study:

  • To analyze the incidence, clinical characteristics, and potential origins of interictal midline spikes.
  • To investigate the association between midline spikes and seizure types.

Main Methods:

  • Retrospective review of 7,929 EEGs performed between 1996 and 2006.
  • Identification of EEGs exhibiting interictal midline spikes at Cz, Fz, or Pz.
  • Analysis of patient demographics, seizure types, and potential etiologies.

Main Results:

  • 17 EEGs (0.21%) showed interictal midline spikes.
  • The majority of affected patients were children (70.6%) with a mean age of 10.8 years.
  • Generalized tonic-clonic seizures were most common (70.6%), followed by partial motor seizures (29.4%).
  • In most cases (82.4%), no specific cause was identified; however, agenesis of corpus callosum and focal brain lesions were noted in some.
  • Midline spikes were predominantly recorded at Cz.

Conclusions:

  • Interictal midline spikes are rare EEG abnormalities, predominantly observed in pediatric patients with epilepsy.
  • The findings suggest a heterogeneous genesis, potentially involving generalized thalamocortical networks or focal parasagittal cortical abnormalities.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications of midline spikes.