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Updated: Jul 6, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Interstitial lung diseases in sarcoidosis].
Diane Bouvry1, Jean-Marc Naccache, Dominique Valeyre
1Service de pneumologie, hôpital Avicenne, GHU Nord, Assistance publique-hôpitaux de Paris et UFR SMBH Bobigny, Uuniversité Paris 13, 93009 Bobigny.
La Revue Du Praticien
|March 7, 2008
Summary
Sarcoidosis is a multisystem granulomatous disorder with unknown causes, often affecting the lungs. While many cases resolve spontaneously, some progress to chronic disease, potentially leading to severe complications.
Area of Science:
- Immunology
- Pulmonology
- Genetics
Background:
- Sarcoidosis is a multisystem disorder of unknown etiology.
- Characterized by immune granuloma formation in various tissues, predominantly the lungs and lymphoid system.
- Potential causes include genetic predisposition and environmental factors.
Purpose of the Study:
- To provide a comprehensive overview of sarcoidosis.
- To discuss diagnostic criteria and staging.
- To outline treatment strategies and prognosis.
Main Methods:
- Review of clinical and radiological findings.
- Histopathological confirmation of non-caseating granulomas.
- Exclusion of other granulomatous diseases.
Main Results:
- Chest X-ray abnormalities (adenopathy, pulmonary infiltration) are present in 90% of cases.
- Classified into 4 stages.
- Spontaneous remission occurs in most cases within 2-3 years; 10-30% develop chronic disease.
- Potential complications include pulmonary fibrosis, respiratory insufficiency, cor pulmonale, and organ-specific lesions.
- Lethality ranges from 0.5% to 5%.
Conclusions:
- Diagnosis requires clinical, radiological, and histological evidence of granulomas.
- Mild cases require no treatment; severe cases are treated with systemic corticosteroids.
- Alternative treatments include antimalarials and immunomodulatory agents.
- Emerging therapies like TNFalpha inhibitors are under evaluation.
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