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Related Experiment Videos

Contrast agents for MRI.

Emily A Waters1, Samuel A Wickline

  • 1Dept. of Cardiology, Washington University Medical School, Campus Box 8215, Cortex Building, Suite 101, 4320 Forest Park Ave., Saint Louis, MO, 63108, USA.

Basic Research in Cardiology
|March 8, 2008
PubMed
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Molecular imaging using magnetic resonance imaging (MRI) offers early cardiovascular disease detection by visualizing biochemical events. This review covers MRI contrast agents for atherosclerosis, thrombus imaging, and stem cell tracking.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Imaging
  • Biomedical Engineering

Background:

  • Cardiovascular diseases are often diagnosed late, focusing on functional deficits.
  • Molecular imaging offers a paradigm shift towards early detection of biochemical precursors.
  • Magnetic resonance imaging (MRI) is a versatile modality for molecular imaging.

Purpose of the Study:

  • To review available molecular magnetic resonance imaging (MRI) contrast agents.
  • To discuss applications of molecular MRI in cardiovascular diseases.
  • To explore opportunities for targeted drug delivery using molecular MRI.

Main Methods:

  • Review of current literature on molecular MRI contrast agents.
  • Discussion of MRI contrast mechanisms for detecting specific molecular targets.

Related Experiment Videos

  • Analysis of applications in atherosclerosis, thrombus imaging, and stem cell tracking.

    • Main Results:

    • A diverse range of molecular MRI contrast agents are available.
    • These agents enable visualization of early disease processes.
    • Applications include atherosclerosis, thrombus detection, and stem cell tracking.

    Conclusions:

    • Molecular MRI holds significant potential to transform cardiovascular medicine.
    • Early detection of biochemical events can lead to improved patient outcomes.
    • Molecularly targeted drug delivery is a promising future application.