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Metabolic programming in the immediate postnatal period.

Malathi Srinivasan1, Mulchand S Patel

  • 1Department of Biochemistry, University at Buffalo, The State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.

Trends in Endocrinology and Metabolism: TEM
|March 11, 2008
PubMed
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Metabolic programming during early life, particularly in the postnatal period, significantly impacts long-term health and contributes to the obesity epidemic. Nutritional changes in this critical window can lead to lasting metabolic consequences.

Area of Science:

  • Metabolic programming and developmental origins of health and disease (DOHaD).

Background:

  • Rising obesity rates in the USA across all age groups.
  • Recognition of metabolic programming's role in obesity etiology.
  • Established link between intrauterine environment and adult-onset diseases.

Purpose of the Study:

  • To highlight the significance of the immediate postnatal period for metabolic programming.
  • To underscore the impact of early nutrition on long-term obesity risk.

Main Methods:

  • Review of existing literature on metabolic programming.
  • Analysis of the role of postnatal nutritional experiences.

Main Results:

  • Vulnerability to metabolic programming extends beyond the intrauterine period into the immediate postnatal phase.

Related Experiment Videos

  • Altered nutrition in early life can induce metabolic programming with long-term effects.

    • Conclusions:

    • The postnatal period is a critical window for metabolic programming.
    • Early nutritional interventions are crucial for mitigating obesity risk.