Related Experiment Video
Updated: Jul 6, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Left ventricular postmyocardial infarction remodeling studied by combining MR-tagging with delayed MR contrast
Nathan Mewton1, Pierre Croisille, Didier Revel
1Centre de Recherche et d'Applications en Traitement de l'Image et du Signal (CREATIS), Unité Mixte de Recherche-CNRS 5515, INSERM 630, Université Claude Bernard Lyon 1, Lyon, France. nathan.mewton@chu-lyon.fr
Objectives:
We sought to monitor the evolution of noninfarcted and infarcted myocardium function in the process of left ventricular (LV) remodeling after a reperfused myocardial infarction.
Material And Methods:
Pigs (n = 8) were subjected to reperfused infarction. Magnetic resonance imaging (MRI) was performed at 3 days and 8 weeks after infarction. Regional circumferential shortening (Ecc) and principal strain L1 in the infarcted, peri-infarcted, and remote myocardium were evaluated by tagged cine MRI combined with matched late enhancement data (Gadolinium-DOTA-enhanced IR-GRE) Global LV function was evaluated by cine MRI. Animals were euthanized after the second imaging session and tissue samples from the different myocardial regions were obtained for histopathologic study.
Results:
There was a significant deterioration in Ecc between the 3-day and 8-week studies in the peri-infarcted myocardium at apex (-9.9% +/- 4.5% to -6.5 +/- 3.9; P = 0.046) whereas it remained stable for all other regions at all levels. A trend toward improvement in Ecc existed in the infarcted myocardium when infarction transmurality was less than 50% of the LV wall (-7.5% +/- 0.8% to -12.2% +/- 2.9% P = 0.06). Ecc in infarcted myocardium was significantly inferior (P < 0.002) to that in remote and peri-infarcted myocardium at the apical level (2.7% +/- 2.6% vs. -14.4% +/- 3.3% and -9.9% +/- 4.5%, respectively). Global LV function substantially deteriorated after infarction and was associated with a significant LV dilation.
Conclusion:
These results confirm the hypothesis that scarred myocardium imposes additional functional burden to the peri-infarcted myocardium.
