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Updated: Jul 6, 2026

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
Published on: October 10, 2016
Standardization of (125)I by the coincidence method and practical applications
Maria Sahagia1, C Ivan, E L Grigorescu
1Horia Hulubei National Institute of R&D for Physics and Nuclear Engineering, 077125 Bucharest, Romania. msahagia@ifin.nipne.ro
Abstract:
A new coincidence system, based on two thin NaI(Tl) crystals, 50 x 2mm(2), with beryllium windows, 1.5mgcm(-2), positioned approximately symmetrically from the source holder (at various distances) was constructed. The electronic chains of a classical 4piPC-gamma system were utilized. A multichannel analyzer was employed for energy calibration, and an oscilloscope for visualization of the pulses. After calibration, the system was used for the standardization of an (125)I solution. An energy window of 12-95keV containing the entire spectrum (single and sum peak) was employed, and a simple demonstration of Taylor's equation [1967. X-ray-X-ray coincidence counting methods for the standardization of (125)I and (197)Hg. In: Standardization of Radionuclides: Proceedings of a International Atomic Energy Agency Symposium, Vienna, 1966, pp. 341-353, SM-79/65] for whole spectrum counting, was developed. The method and system were tested during the calibration of a LKB 2104 multi-gamma counter, by comparing the detection efficiency values obtained for this prepared standard solution and that utilized in the CIPM-CCRI(II) key comparison. The efficiency of the equipment was calculated as the mean of the two individual values. The result validates the method and demonstrates the accomplishment of the national traceability assurance in nuclear medicine for (125)I.
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