Dysphagia with a thyroid nodule: is there a primary aerodigestive malignancy?

Area of Science:

• Oncology
• Otolaryngology
• Head and Neck Surgery

Background:

• Squamous cell carcinoma (SCC) is a common malignancy.
• Laryngopharyngeal cancers can present with varied symptoms.
• Thyroid nodules are frequently encountered in clinical practice.

Observation:

• Three cases are presented where laryngopharyngeal primary squamous cell carcinoma manifested as a thyroid nodule.
• These cases highlight an unusual but significant presentation of upper aerodigestive tract malignancy.

Findings:

• Patients with advanced laryngopharyngeal SCC may present with a palpable thyroid nodule.
• The thyroid nodule in these cases was a presenting sign of a more extensive malignancy.

Implications:

• Clinicians should consider advanced upper aerodigestive tract malignancy in patients presenting with thyroid nodules.
• Early recognition of this association can improve diagnostic pathways and patient outcomes.
• This underscores the importance of a thorough head and neck examination in patients with thyroid findings.