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Prototype micropump for insulin administration based on electrochemical bubble formation.

Ayumi Kabata1, Kentaro Okamura, Hiroaki Suzuki

  • 1Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.

Journal of Pharmaceutical Sciences
|March 21, 2008
PubMed
Summary

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Researchers developed a novel artificial pancreas islet using micromachining. This insulin injection micropump effectively lowered plasma glucose levels in diabetic rats, demonstrating its potential for diabetes management.

Area of Science:

  • Biomedical Engineering
  • Microsystems Engineering

Background:

  • Diabetes mellitus management requires precise insulin delivery.
  • Existing artificial pancreas technologies face challenges in miniaturization and efficient insulin delivery.

Purpose of the Study:

  • To fabricate and evaluate an insulin injection micropump for a percutaneous artificial pancreas islet.
  • To assess the controlled insulin delivery and in vivo efficacy of the developed micropump.

Main Methods:

  • Micromachining techniques were employed to create the micropump, integrating a thin-film, two-electrode system, silicone diaphragm, insulin reservoir, and microneedle.
  • Electrochemical actuation generated hydrogen bubbles to deform the diaphragm, enabling controlled insulin injection.
  • The micropump's performance was evaluated in streptozotocin-induced diabetic rats, measuring plasma glucose levels post-injection.

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Last Updated: Jul 6, 2026

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A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
07:55

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Published on: January 26, 2010

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Main Results:

  • The micropump demonstrated smooth insulin injection with controllable rates via electrode potential or current.
  • In vivo studies showed a dose-dependent decrease in plasma glucose levels in diabetic rats.
  • The micropump's efficacy was comparable to manual insulin injection.

Conclusions:

  • A functional insulin injection micropump was successfully fabricated using micromachine techniques.
  • The device offers a promising approach for controlled insulin delivery in artificial pancreas systems.
  • This technology has the potential to improve glycemic control in diabetes management.