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Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

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Corrigendum to "Artemisinin protects DPSC from hypoxia and TNF-α mediated osteogenesis impairments through CA9 and Wnt signaling pathway" [Life Sci. 277 (2021) 119471].

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Artemisinin protects DPSC from hypoxia and TNF-α mediated osteogenesis impairments through CA9 and Wnt signaling pathway.

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cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2015
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Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2014
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The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory.

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Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli.

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Related Experiment Video

Updated: Jul 6, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

[Synaptic tagging in process of long-term synaptic plasticity].

Mu-Hua Mao1, Zong-Sheng Liu, Jiang-Yuan Hu

  • 1Medical College of Jinggangshan University, Jiangxi Jian 343000, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|March 25, 2008
PubMed
Summary

Synaptic tagging enables activated synapses to capture necessary proteins for long-term memory formation. This mechanism is crucial for stabilizing synaptic plasticity, the basis of learning and memory.

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Presynaptically Silent Synapses Studied with Light Microscopy
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Presynaptically Silent Synapses Studied with Light Microscopy

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3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Related Experiment Videos

Last Updated: Jul 6, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Context:

  • Long-term synaptic plasticity underpins learning and memory.
  • Maintaining late phases of plasticity requires gene transcription and translation.
  • Efficient targeting of gene products to specific synapses is a key challenge.

Purpose:

  • To review advancements in understanding synaptic tagging.
  • To explain how synapses are marked to capture plasticity-related proteins.

Summary:

  • Synaptic plasticity, essential for learning and memory, relies on gene expression.
  • A 'synaptic tag' marks activated synapses, enabling them to capture and utilize proteins.
  • This process stabilizes synaptic plasticity from early to late phases.

Impact:

  • Provides insights into the molecular mechanisms of memory consolidation.
  • Highlights the role of synaptic tagging in localizing molecular machinery for plasticity.
  • Advances our understanding of how neuronal connections are modified for long-term storage.