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Related Experiment Video

Updated: Jul 6, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Autoimmunity in coxsackievirus infection.

¹Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, 615 N. Wolfe St., E5009, Baltimore, MD 21205, USA. nrrose@jhmi.edu

Current Topics in Microbiology and Immunology

|March 25, 2008

Summary

Viral infections can trigger autoimmune diseases like myocarditis. Early cytokine production, including IL-1beta and TNFalpha, determines if a viral infection progresses to pathogenic autoimmunity in susceptible individuals.

Area of Science:

Immunology
Virology
Cardiology

Background:

Viral infections can induce autoantibodies, sometimes leading to autoimmune diseases.
Autoimmune myocarditis is a significant concern, particularly following viral infections.
Understanding the mechanisms of virus-induced autoimmunity is crucial for preventing autoimmune diseases.

Purpose of the Study:

To investigate the mechanisms underlying the induction of autoimmune disease following viral infection.
To delineate the critical early events that determine the progression from viral myocarditis to pathogenic autoimmunity.
To explore the role of specific cytokines in the development of autoimmune sequelae.

Main Methods:

Utilized a mouse model of autoimmune myocarditis induced by cardiotropic coxsackievirus B3 infection.

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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

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Simulated autoimmune sequelae by immunizing susceptible mice with murine cardiac myosin.

Analyzed the early cytokine production (IL-1beta, TNFalpha) within hours of infection induction.

Main Results:

Viral infections can trigger pathogenic autoimmunity, leading to autoimmune disease.
The progression from viral myocarditis to autoimmune response is determined within hours post-infection.
Key cytokines, including IL-1beta and TNFalpha, play a critical role in this determination.

Conclusions:

The study provides insights into the mechanisms of virus-induced autoimmune myocarditis.
Early cytokine responses are critical determinants of autoimmune disease development after viral infection.
Findings are applicable to understanding human myocarditis and dilated cardiomyopathy.