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Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis

Keijiro Nakamura1, Takanobu Tomaru, Shigeo Yamamura

  • 1Department of Cardiovascular Center, Sakura Medical Center, School of Medicine, Toho University, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|March 26, 2008
PubMed

Insights

Cardio-ankle vascular index (CAVI) effectively identifies coronary atherosclerosis severity. This arterial stiffness measure proved superior to carotid ultrasound in predicting coronary artery disease progression in a study of 109 participants.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Imaging

Background:

  • Arterial stiffness is a key indicator of cardiovascular health.
  • The cardio-ankle vascular index (CAVI) is a novel parameter for assessing arterial stiffness.
  • Coronary atherosclerosis severity assessment is crucial for cardiovascular risk stratification.

Purpose of the Study:

  • To evaluate the efficacy of CAVI in reflecting coronary atherosclerosis severity.
  • To compare CAVI's performance against carotid atherosclerosis parameters derived from B-mode ultrasonography.

Main Methods:

  • 109 participants undergoing coronary angiography (CAG) were analyzed.
  • Participants were stratified into groups based on the number of stenotic vessels (0VD, 1VD, 2VD, 3VD).
  • CAVI and carotid atherosclerosis metrics (intima-media thickness, plaque score) were measured and correlated with CAG findings.

Main Results:

  • CAVI values significantly increased with the number of stenotic vessels in the coronary arteries (p<0.05).
  • CAVI demonstrated a positive correlation with maximum intima-media thickness (p<0.01) and plaque score (p<0.0001).
  • Ordinal logistic regression identified CAVI as the sole significant predictor of coronary atherosclerosis severity, with the largest area under the ROC curve.

Conclusions:

  • CAVI is a valuable non-invasive marker for assessing the severity of coronary atherosclerosis.
  • CAVI may offer superior diagnostic utility compared to carotid atherosclerosis assessments using B-mode ultrasonography.
Abstract

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