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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Quantifying postoperative bone loss in children.

Elizabeth A Szalay1, Debra Harriman, Brittany Eastlund

  • 1University of New Mexico Health Sciences Center, 1127 University Blvd NE, Albuquerque, NM 87102, USA. ESzalay@salud.unm.edu

Journal of Pediatric Orthopedics
|March 26, 2008
PubMed
Summary
This summary is machine-generated.

Children can experience significant bone density loss after lower extremity surgery, losing up to 34% of bone mineral density (BMD) in just 4-6 weeks. This highlights the need for preventative strategies and treatments to mitigate fracture risk in pediatric patients.

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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology

Published on: December 7, 2011

Area of Science:

  • Pediatric Orthopedics
  • Bone Metabolism
  • Radiology

Background:

  • Postoperative bone density loss in children is a recognized issue.
  • Objective quantification of this bone loss has been lacking.
  • Dual-energy x-ray absorptiometry (DXA) is used to assess bone mineral density (BMD).

Purpose of the Study:

  • To objectively quantify bone density loss in children following lower extremity surgery.
  • To compare preoperative and postoperative BMD and Z-scores.
  • To evaluate changes in operated versus non-operated limbs.

Main Methods:

  • Prospective diagnostic study (Level I evidence).
  • Recruited children undergoing lower extremity surgery requiring immobilization (≥4 weeks).
  • Performed preoperative and postoperative DXA scans of the lumbar spine and distal femora; analyzed BMD and Z-scores.

Main Results:

  • Children lost up to 34% BMD in the cancellous region (average 16.5%) of the operated leg.
  • Significant BMD loss observed in transitional (average 11.5%) and cortical (average 4.8%) bone regions (P < 0.05).
  • Z-scores decreased by 1.0 SD (cancellous), 0.75 SD (transitional), and 0.45 SD (cortical).

Conclusions:

  • Pediatric bone density loss of up to 34% can occur within 4-6 weeks post-surgery.
  • A 1 SD drop in Z-score may significantly increase fracture risk, especially in chronically ill children.
  • Proactive prevention and treatment strategies are crucial to address this bone loss.