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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
Published on: October 15, 2013
Chemical modification of polymeric microchip devices.
1Mass Spectrometry Research Group, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, D-07745 Jena, Germany. amuck@ice.mpg.de
Talanta
|March 29, 2008
Summary
Chemical modifications enhance analytical polymeric microchips for faster, cheaper, and more efficient lab-on-a-chip applications. These advancements improve performance in areas like electrophoresis and analyte extraction.
Area of Science:
- Analytical Chemistry
- Materials Science
- Chemical Engineering
Background:
- Polymeric microchips offer advantages like speed, low consumption, and cost-effectiveness.
- Limitations in bulk polymer properties necessitate advanced modification strategies.
Purpose of the Study:
- To critically review chemical modification strategies for analytical polymeric microchips developed since 2003.
- To highlight the impact of these modifications on lab-on-a-chip technology.
Main Methods:
- Surface modification via chemical derivatization or activation using reagents, gases, and irradiation.
- Bulk modification through monomer incorporation for integrated fabrication and functionalization.
Main Results:
- Developed strategies for surface and bulk modification of polymeric microchips.
- Demonstrated applications in modulating electroosmosis and suppressing protein adsorption.
- Showcased utility in analyte extraction and zone-specific biomolecule binding.
Conclusions:
- Chemical modifications significantly enhance the capabilities of polymeric microchips.
- These advancements pave the way for true lab-on-a-chip systems with diverse applications.
