What to do with an abnormal PSA test
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Updated: Jul 6, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Stacy Loeb1, William J Catalona
1Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Abstract:
For more than a decade, prostate-specific antigen (PSA) has been used for prostate cancer screening. Over the years, this screening has been continually refined, including investigation into the use of lower total PSA thresholds, PSA isoforms, and PSA kinetics. This review describes the evolution of prostate cancer screening and provides clinical insights into the informed use of PSA and its adjunctive measurements.
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