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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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Replicative Cell Senescence

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Nucleosome Remodeling02:54

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
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Nondisjunction01:21

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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.

Jesús Espada1, Ignacio Varela, Ignacio Flores

  • 1Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

The Journal of Cell Biology
|April 2, 2008
PubMed
Summary
This summary is machine-generated.

Nuclear lamina defects in Zmpste24-null mice impair epidermal stem cell function and number. These age-related nuclear envelope changes impact stem cell homeostasis, highlighting a link to stem cell dysfunction.

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Nuclear Transfer into Mouse Oocytes
14:17

Nuclear Transfer into Mouse Oocytes

Published on: November 30, 2006

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Last Updated: Jul 6, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

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Nuclear Transfer into Mouse Oocytes
14:17

Nuclear Transfer into Mouse Oocytes

Published on: November 30, 2006

Area of Science:

  • Cell Biology
  • Stem Cell Biology
  • Aging Research

Background:

  • Nuclear lamina alterations are observed in physiological aging and premature aging syndromes.
  • Aging is linked to abnormal stem cell homeostasis.

Purpose of the Study:

  • To investigate the impact of nuclear envelope alterations on stem cell compartments.
  • To evaluate stem cell number and function in Zmpste24-null progeroid mice with nuclear lamina defects.

Main Methods:

  • Examined stem cell number and functional competence in Zmpste24-null progeroid mice.
  • Analyzed nuclear architecture, apoptosis, and molecular signaling pathways (Wnt, microphthalmia transcription factor).
  • Utilized Zmpste24(-/-)Lmna(+/-) mutant mice for rescue experiments.

Main Results:

  • Zmpste24 deficiency altered epidermal stem cell number and proliferation.
  • Aberrant nuclear architecture in bulge cells and increased apoptosis in supporting cells were observed.
  • These defects were rescued in Zmpste24(-/-)Lmna(+/-) mice.
  • Molecular signaling pathways regulating stem cell behavior were altered in Zmpste24(-/-) mice.

Conclusions:

  • Nuclear envelope defects are linked to stem cell dysfunction.
  • Age-related nuclear lamina alterations impact stem cell homeostasis and function.
  • This study establishes a connection between nuclear envelope integrity and stem cell maintenance.