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Endurance training modulates lymphocyte function in rats with post-MI CHF.

Miguel Luiz Batista1, Ronaldo V T Santos, Renato D Lopes

  • 1Molecular Biology of the Cell Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. migueljr@usp.br

Medicine and Science in Sports and Exercise
|April 2, 2008
PubMed
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Moderate endurance exercise training in post-myocardial infarction (MI) rats with congestive heart failure (CHF) improved lymphocyte function and increased interleukin-2 (IL-2) production, potentially reversing immune imbalances.

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Exercise Physiology

Background:

  • Exercise training can restore innate immune cell function after myocardial infarction (MI).
  • The role of lymphocytes (Ly) in congestive heart failure (CHF) post-MI requires further investigation.

Purpose of the Study:

  • To investigate lymphocyte function in cervical lymph nodes of post-MI CHF rats subjected to treadmill training.
  • To assess the impact of exercise on immune cell proliferation and cytokine production in a post-MI CHF model.

Main Methods:

  • Wistar rats were divided into sedentary and trained groups: myocardial infarction (MI) or sham-operated.
  • Lymphocyte proliferation (using [2-C]-thymidine), cytokine production (IL-2, IL-4), and plasma glutamine were measured post-training.
  • Training involved treadmill running for 8-10 weeks.

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Main Results:

  • Lymphocyte proliferative capacity increased in MI groups compared to sham groups after Con-A stimulation.
  • Sedentary MI rats produced significantly more IL-4 when stimulated with PHA compared to sedentary sham rats.
  • Treadmill training significantly increased IL-2 production in lymphocytes from MI rats.

Conclusions:

  • Moderate endurance training increased IL-2 production in post-MI CHF rats.
  • Exercise training showed a trend towards reversing the Th1/Th2 imbalance associated with increased IL-4 production in this model.