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Thermal Measurement Techniques in Analytical Microfluidic Devices
Published on: June 3, 2015
Numerical analysis of thermal lens effect for sensitive detection on microchips
Ryo Anraku1, Kazuma Mawatari, Manabu Tokeshi
1Technical Research Laboratory, Nippon Sheet Glass Co. Ltd., Osaka, Japan.
Electrophoresis
|April 9, 2008
Summary
A new flexible design tool for thermal lens microscopy (TLM) systems was developed. This tool accurately models and predicts TLM performance, simplifying the design of sensitive detection systems for microfluidic applications.
Area of Science:
- Analytical Chemistry
- Optical Physics
- Microfluidics
Background:
- Thermal lens microscopy (TLM) is a sensitive technique for detecting nonfluorescent analytes.
- TLM is frequently used in capillary and microchip-based detection systems.
- Designing TLM systems for specific microscale applications can be complex.
Purpose of the Study:
- To develop a flexible design tool for thermal lens microscopy (TLM) systems.
- To enable tailored TLM system designs for diverse microspace applications.
- To improve the predictability and ease of TLM system development.
Main Methods:
- Modeled the thermal lens (TL) effect, incorporating signal processing.
- Combined fluid dynamics and wave optics software for calculations.
- Investigated the impact of optical path length and excitation beam focus on TL signals.
Main Results:
- Achieved good agreement between calculated and experimental results.
- Demonstrated accurate prediction of TL signals, even for parameters difficult to compute conventionally.
- Verified the applicability and effectiveness of the developed TLM design tool.
Conclusions:
- The developed design tool offers a flexible approach to TLM system engineering.
- The tool accurately predicts TLM performance, facilitating application-specific designs.
- This advancement simplifies the creation of sensitive microscale detection systems using TLM.
