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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Current status of carotid stenting
Ji Sun Kim1, Debabrata Mukherjee
1Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536-0200, USA.
Current Vascular Pharmacology
|April 9, 2008
Summary
Stroke is a leading cause of death and disability. Carotid stenting, with emboli protection devices, offers a growing treatment option for internal carotid artery stenosis, alongside optimal medical therapy.
Area of Science:
- Neurology
- Vascular Surgery
- Public Health
Background:
- Stroke is a major global cause of death and disability, with significant healthcare costs.
- Internal carotid artery stenosis accounts for 10-20% of all strokes and transient ischemic attacks.
- Carotid endarterectomy (CEA) is proven effective for high-grade stenosis, especially in symptomatic patients.
Purpose of the Study:
- To review studies on carotid stenting for internal carotid artery stenosis.
- To discuss the appropriate use of percutaneous carotid revascularization.
- To emphasize optimal long-term pharmacotherapy for patients with carotid stenosis.
Main Methods:
- Review of available studies on carotid stenting procedures.
- Analysis of the impact of emboli protection devices (EPDs).
- Discussion of comparative effectiveness of CEA versus stenting.
Main Results:
- Carotid stenting, particularly with EPDs, has seen exponential growth since 2000.
- CEA remains a superior option for specific patient groups with high-grade stenosis.
- The role of percutaneous carotid revascularization is expanding.
Conclusions:
- Carotid stenting is an increasingly utilized procedure for internal carotid artery stenosis.
- Careful patient selection and the use of EPDs are crucial for safety and efficacy.
- Long-term pharmacotherapy is essential for managing patients with carotid stenosis.
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