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Embryonic pattern formation without morphogens.

Hamid Bolouri1

  • 1Institute for Systems Biology, Seattle, 1441 N 34th St, Seattle WA 98103, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 12, 2008
PubMed
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Early embryonic development relies on endoderm and mesoderm specification. In sea urchin embryos, gene expression patterns for these tissues are precisely controlled by cis-regulatory logic.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Endoderm and mesoderm specification are fundamental early embryonic events.
  • In sea urchin embryos, blimp1 and wnt8 gene expression initiates this process at the vegetal pole.
  • This gene expression pattern dynamically shifts during early development.

Purpose of the Study:

  • To investigate the regulatory mechanisms controlling the dynamic spatial and temporal expression of blimp1 and wnt8 during sea urchin embryonic development.
  • To determine if transcriptional cis-regulatory logic governs the observed "moving ring" of gene expression.

Main Methods:

  • Analysis of gene expression patterns (blimp1 and wnt8) in sea urchin embryos at key developmental stages.
  • Computational and experimental investigation of cis-regulatory elements controlling gene expression.

Related Experiment Videos

  • Focus on the transition of gene activity from mesoderm progenitors to endoderm cells.

    • Main Results:

    • Gene expression of blimp1 and wnt8 initially occurs at the vegetal pole and subsequently spreads.
    • A dynamic "ring" of wnt8/blimp1 activity is observed, moving from mesoderm progenitors to endoderm cells.
    • This dynamic gene expression pattern is demonstrated to be entirely controlled by transcriptional cis-regulatory logic.

    Conclusions:

    • The precise spatial and temporal control of endoderm and mesoderm specification in sea urchin embryos is achieved through intricate cis-regulatory mechanisms.
    • A moving ring of gene expression, governed by cis-regulatory logic, orchestrates cell fate decisions during early development.