Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genes and osteoporosis.

S F Grant1, S H Ralston

  • 1Department of Medicine and Therapeutics, Bone Research Group, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.

Trends in Endocrinology and Metabolism: TEM
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Anti-rheumatic Drugs on the Skeleton.

Calcified tissue international·2022
Same author

Risk of severe COVID-19 in patients with inflammatory rheumatic diseases treated with immunosuppressive therapy in Scotland.

Scandinavian journal of rheumatology·2022
Same author

Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical Guidance.

Calcified tissue international·2021
Same author

Rheumatology in a time of Coronavirus: lessons from our early experiences.

QJM : monthly journal of the Association of Physicians·2020
Same author

Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus.

Lupus·2018
Same author

High mortality in younger patients with major osteoporotic fractures.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
Same journal

Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism.

Trends in endocrinology and metabolism: TEM·2026
Same journal

HDL resuscitates cells from ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

2-Methylbutyrylcarnitine (2MBC).

Trends in endocrinology and metabolism: TEM·2026
Same journal

Decoding growth hormone actions on human growth plate stem cells.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Androgen loss backfires: Brain gate for tumor immunity.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Glucocorticoid resistance-induced inflammation drives cardiovascular-kidney-metabolic (CKM) syndrome pathophysiology.

Trends in endocrinology and metabolism: TEM·2026
See all related articles

Genetic factors significantly influence bone density and osteoporosis risk. A specific collagen type I alpha 1 gene polymorphism is linked to lower bone mass and increased fracture risk, aiding in risk assessment.

Area of Science:

  • Bone biology and genetics
  • Osteoporosis research

Background:

  • Osteoporosis is a prevalent condition characterized by reduced bone mineral density.
  • Genetics significantly contributes to bone mass regulation, accounting for up to 75% of its variance.
  • Previous research identified polymorphisms in various candidate genes, with inconsistent results.

Purpose of the Study:

  • To investigate the genetic underpinnings of osteoporosis and bone mass.
  • To identify specific gene polymorphisms associated with bone density and fracture risk.

Main Methods:

  • Segregation analysis of bone mass in families.
  • Association studies of candidate gene polymorphisms with bone mass and osteoporotic fracture.
  • Identification of a polymorphism in the collagen type I alpha 1 gene's Sp1 binding site.

Related Experiment Videos

Main Results:

  • Bone mass appears to be controlled by numerous genes with small effects.
  • A polymorphism in the collagen type I alpha 1 gene is associated with bone mass and osteoporotic fracture across three populations.
  • This polymorphism may serve as a marker for low bone density and fracture risk.

Conclusions:

  • Genetic factors are crucial in osteoporosis pathogenesis.
  • The identified collagen type I alpha 1 gene polymorphism shows promise for assessing fracture risk.
  • Further genetic discoveries may lead to novel therapeutic targets and genetic testing for osteoporosis.