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Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Antiplatelet agents and arterial thrombosis
1Albert Einstein College of Medicine, Thrombosis Prevention and Treatment Program, Department of Medicine, Division of Hematology, Montefiore Medical Center, Bronx, NY 10467, USA. hbillet@montefiore.org
Cardiology Clinics
|April 15, 2008
Summary
Elderly individuals face higher arterial thrombotic event risks due to age and comorbidities. Despite underuse, antiplatelet therapies like aspirin and clopidogrel show potential in managing these risks in older adults.
Area of Science:
- Geriatric Medicine
- Cardiovascular Medicine
- Pharmacology
Background:
- Arterial thrombotic events disproportionately increase in the elderly.
- Elderly patients often have comorbidities like diabetes, hypertension, and hypercholesterolemia, exacerbating risk.
- Antithrombotic therapy is underutilized in geriatric patients, even when contraindications are considered.
Purpose of the Study:
- To review the efficacy of available antiplatelet agents in elderly patients.
- To assess the effects of aspirin, clopidogrel, and glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonists in various disease states within the geriatric population.
Main Methods:
- Review of current antiplatelet agents: aspirin, clopidogrel, and GPIIb/IIIa antagonists.
- Analysis of clinical data focusing on the geriatric population.
- Assessment of drug effects across different disease states relevant to the elderly.
Main Results:
- The article examines the mechanisms of action for key antiplatelet drugs.
- It specifically analyzes data pertaining to the use and effectiveness of these agents in older adults.
- The review highlights the disproportionate increase in arterial ischemic event risk when age is combined with other predisposing factors.
Conclusions:
- Antiplatelet therapy remains underused in the elderly, despite its potential benefits.
- Further research and clinical attention are needed to optimize antithrombotic strategies for geriatric patients.
- Understanding the specific effects of agents like aspirin and clopidogrel in elderly populations is crucial for improving outcomes.
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