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Related Concept Videos

Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
Feedback Loops01:01

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

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Related Experiment Video

Updated: Jul 6, 2026

Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion
05:58

Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion

Published on: July 4, 2018

Pulsatile patterns in hormone secretion.

G Brabant1, K Prank, C Schofl

  • 1Georg Brabant, Klaus Prank, and Christoph Schofl are at the Department of Clinical Endocrinology, Medizinische Hochschule Hannover, D-3000 Hannover 61, Germany.

Trends in Endocrinology and Metabolism: TEM
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Hormone levels fluctuate in pulses, not continuously. Understanding this pulsatile secretion is crucial for diagnosing and treating endocrine diseases, especially those involving pituitary hormones.

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Last Updated: Jul 6, 2026

Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion
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Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Physiology

Background:

  • Endocrine systems exhibit dynamic regulation.
  • Hormonal information is encoded in pulses varying in frequency (minutes to hours).
  • Sensitive hormone measurement and high-frequency blood sampling reveal pulsatile secretion patterns.

Purpose of the Study:

  • To review the relevance of pulsatile hormone secretion in endocrine system regulation.
  • To discuss the implications of pulsatile secretion for diagnosing and treating endocrine diseases.
  • To use pituitary hormones as a key example.

Main Methods:

  • Literature review focusing on pulsatile secretion patterns.
  • Analysis of studies employing sensitive hormone measurements.
  • Examination of high-frequency blood sampling techniques.

Main Results:

  • Pulsatile secretion is a fundamental characteristic of many endocrine systems.
  • The frequency and amplitude of hormone pulses convey critical regulatory information.
  • Pituitary hormone secretion exemplifies the significance of pulsatile patterns.

Conclusions:

  • Pulsatile hormone secretion is vital for physiological regulation.
  • Disruption of pulsatile patterns can lead to endocrine disorders.
  • Understanding pulsatility improves diagnostic accuracy and therapeutic strategies for endocrine diseases.