Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acromegaly.

A L Barkan1

  • 1Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, MI 48109-0354, USA.

Trends in Endocrinology and Metabolism: TEM
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Acromegaly is typically caused by pituitary tumors secreting excess growth hormone (GH). Understanding the causes and pathophysiology of acromegaly is crucial for effective treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of pulsatile growth hormone (GH) secretion in the regulation of lipolysis in fasting humans.

Clinical diabetes and endocrinology·2022
Same author

Acromegalic arthropathy.

Pituitary·2002
Same author

Pergolide as primary therapy for macroprolactinomas.

Pituitary·2002
Same author

Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist.

Lancet (London, England)·2001
Same author

Semiquantification of hypothalamic GH-releasing hormone output in women: evidence for sexual dimorphism in the mechanism of the somatopause.

The Journal of clinical endocrinology and metabolism·2001
Same author

Regulation of GH secretion in acromegaly: reproducibility of daily GH profiles and attenuated negative feedback by IGF-I.

The Journal of clinical endocrinology and metabolism·2001
Same journal

Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism.

Trends in endocrinology and metabolism: TEM·2026
Same journal

HDL resuscitates cells from ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

2-Methylbutyrylcarnitine (2MBC).

Trends in endocrinology and metabolism: TEM·2026
Same journal

Decoding growth hormone actions on human growth plate stem cells.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Androgen loss backfires: Brain gate for tumor immunity.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Glucocorticoid resistance-induced inflammation drives cardiovascular-kidney-metabolic (CKM) syndrome pathophysiology.

Trends in endocrinology and metabolism: TEM·2026
See all related articles

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Acromegaly results from excessive growth hormone (GH) secretion, predominantly from pituitary somatotroph tumors.
  • The precise etiology of acromegaly remains largely unknown, with potential links to GHRH hypersecretion or intrinsic pituitary defects.

Observation:

  • Recent advancements in physiological data and molecular biology offer new insights into the condition's pathophysiology.
  • Pituitary tumors are the primary cause in most acromegaly cases.

Findings:

  • The pathophysiology of acromegaly involves complex interactions possibly including GHRH hypersecretion or intrinsic pituitary abnormalities.
  • Molecular biology techniques are enhancing our understanding of GH hypersecretion mechanisms.

Related Experiment Videos

Implications:

  • Effective treatment strategies for acromegaly involve a multimodal approach.
  • Therapeutic options encompass surgery, radiation therapy, and pharmacologic agents targeting GH secretion and tumor growth.