[High resolution MRI of carotid atherosclerosis: looking beyond the arterial lumen]
C Oppenheim1, E Touzé, X Leclerc
1Département d'Imagerie Morphologique et Fonctionnelle, Centre Hospitalier Sainte-Anne, 1, rue Cabanis, 75674 Paris Cedex 14, France. c.oppenheim@ch-sainte-anne.fr
Insights
High-resolution MRI (HR-MRI) visualizes carotid atherosclerosis components, aiding stroke risk assessment. This advanced imaging may guide future atherosclerosis management and treatment evaluation.
Area of Science:
- Cardiovascular Imaging
- Neuroimaging
- Vascular Biology
Context:
- Atherosclerosis is a leading global cause of mortality.
- Cervical artery imaging, particularly carotid atherosclerosis, benefits from technical advancements.
- High-resolution MRI (HR-MRI) enables detailed visualization of atherosclerotic plaque within vessel walls.
Purpose:
- To highlight the capabilities of HR-MRI in characterizing atherosclerotic plaque components.
- To explore the role of HR-MRI in stroke risk stratification.
- To discuss the potential of HR-MRI in monitoring treatment efficacy for atherosclerosis.
Summary:
- HR-MRI provides detailed visualization of atherosclerotic plaque components, including necrotic lipid core, intraplaque hemorrhage, calcifications, and fibrous cap.
- Quantitative analysis of global plaque volume and individual component volumes is achievable with HR-MRI.
- Plaque structure analysis and stenosis measurement using HR-MRI aid in stratifying stroke risk.
Impact:
- HR-MRI facilitates a more precise assessment of atherosclerotic plaque vulnerability.
- This imaging modality can inform treatment strategies aimed at plaque stabilization or regression.
- Direct evaluation of the vessel wall via HR-MRI is poised to transform atherosclerosis management.
Abstract:
Despite advances in diagnosis and treatment, atherosclerosis remains the second cause of death in the world. Due to technical advances, high resolution MRI (HR-MRI) allows depiction of the wall of cervical arteries, especially carotid atherosclerosis. HR-MRI allows visualization of the different components of atherosclerosis: necrotic lipid core, intraplaque hemorrhage, calcifications and fibrous cap. Global plaque volume as well as the volumes of individual plaque components can be calculated. Atherosclerotic plaque structure analysis, along with stenosis measurement, contribute to the stratification of the stroke risk. HR-MRI may also be used to assess treatment efficacy aimed at stabilizing or reducing plaque progression. Beyond the arterial lumen, direct evaluation of vessel wall should modify the management of atherosclerosis in the years to come.
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