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Published on: July 17, 2020
First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid
Marcellino Rudyanto1, Yuichiro Tomizawa, Hiroshi Morita
1Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Organic Letters
|April 17, 2008
Abstract:
The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6- endo-dig-cyclization of phenolic oxygens to the resulting alkynes.

