Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closing the dietary fibre gap - developing a novel dietary fibre screening tool (SCREEN-IT) for the UK population: validity, reproducibility and usability insights.

European journal of nutrition·2026
Same author

Advancing digital nutrition assessment: Development and evaluation of the UK eNutriFFQv2.0.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same author

"Why isn't fibre mentioned more often?" Conducting focus groups with an ageing population to promote dietary fibre-related awareness and starting the conversation.

Appetite·2026
Same author

An overview of the UK Scientific Advisory Committee on Nutrition's assessments and recommendations on processed foods and sweeteners.

The British journal of nutrition·2026
Same author

Reply to Rebelo and Tanus-Santos.

The Journal of nutrition·2026
Same author

Association of lipoprotein lipase genetic risk score with cardiometabolic risk indicators in a healthy Qatari population using the Qatar Biobank data.

PloS one·2026

Related Experiment Video

Updated: Jul 5, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Nutrigenetics and CVD: what does the future hold?

Julie A Lovegrove1, Rachel Gitau

  • 1Department of Food Biosciences, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Whiteknights, PO Box 226, Reading, Berks. RG6 6AP, UK. j.a.lovegrove@reading.ac.uk

The Proceedings of the Nutrition Society
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Personalized nutrition, or nutrigenetics, tailors dietary advice to an individual's genetic makeup. This approach shows promise for reducing cardiovascular disease (CVD) risk, addressing limitations of general public health recommendations.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Cardiovascular disease research
  • Nutrigenetics and personalized nutrition
  • Human genetics and diet interactions

Background:

  • Cardiovascular disease (CVD) remains a leading cause of mortality globally, driven by multifactorial environmental and genetic influences.
  • Population-based dietary recommendations have shown limited success in mitigating CVD risk due to significant individual variability in response.
  • Nutrigenetics, the study of diet-gene interactions, offers a basis for personalized nutritional strategies to improve health outcomes.

Purpose of the Study:

  • To review the current evidence on interactions between dietary fat intake and specific genetic polymorphisms related to CVD risk.
  • To explore the potential of personalized nutrition, informed by genetic profiling, as a strategy for cardiovascular disease prevention.
  • To highlight the growing body of research investigating gene-diet interactions and their impact on individual health.

Main Methods:

  • Literature review focusing on interactions between dietary fat and polymorphisms in apoE, apoAI, and PPARgamma genes.
  • Analysis of evidence linking genetic variants to nutrient intake and cardiovascular disease biomarkers.
  • Examination of the concept of nutrigenetics and its application in tailored dietary recommendations.

Main Results:

  • Evidence for interactions between dietary fat and common gene polymorphisms (apoE, apoAI, PPARgamma) influencing CVD risk is increasing but remains limited.
  • Individual genetic makeup significantly affects responses to dietary interventions, underscoring the need for personalized approaches.
  • Understanding gene-diet interactions is crucial for advancing personalized nutrition strategies.

Conclusions:

  • Personalized nutritional advice, based on genotyping, holds potential for more effective CVD risk reduction compared to general recommendations.
  • Further research into gene-diet interactions is essential to refine personalized nutrition strategies.
  • Ethical considerations surrounding the routine implementation of genetically tailored dietary advice require careful evaluation.