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Updated: Jul 5, 2026
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
Visualization of brown adipose tissue with 99mTc-methoxyisobutylisonitrile on SPECT/CT
Sibyll Goetze1, William C Lavely, Harvey A Ziessman
1Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21287-0817, USA.
Unlabelled:
Brown adipose tissue (BAT) is retained into adulthood in some patients. It has been imaged using several radiopharmaceuticals, including (18)F-FDG. Using SPECT/CT, we assessed whether and how frequently uptake of (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) was present in expected locations of BAT.
Methods:
A total of 205 SPECT/CT scans using (99m)Tc-MIBI for parathyroid imaging were reviewed for the presence of (99m)Tc-MIBI uptake in expected locations of BAT.
Results:
We detected (99m)Tc-MIBI uptake in BAT in 13 of 205 patients (6.3%). When BAT was visualized, it was detected on both early and delayed scans. The patients with (99m)Tc-MIBI uptake in BAT were younger than the patients with no (99m)Tc-MIBI uptake (P=0.044).
Conclusion:
Uptake of (99m)Tc-MIBI in BAT is relatively common in this adult patient population and should not be confused with (99m)Tc-MIBI-avid-tumors. SPECT/CT can be useful for defining such tracer uptake as a normal physiologic variant.
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