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68 Ga-DOTATATE and 18 F-FDG PET/CT in a Rapidly Progressing Lymphoma

Ashwin Singh Parihar1, Richard L Wahl, Amin H Jahromi

  • 1From the Mallinckrodt Institute of Radiology and Siteman Cancer Center, Washington University School of Medicine, St Louis, MO.

Clinical Nuclear Medicine
|October 14, 2024
PubMed

68 Ga-DOTATATE PET/CT targeting somatostatin receptors is commonly utilized in the imaging of neuroendocrine tumors. However, other malignancies such as lymphomas (both Hodgkin and non-Hodgkin) also have expression of somatostatin receptors, albeit to a lesser degree compared with the neuroendocrine tumors, and thus can be positive on a 68 Ga-DOTATATE PET/CT. We describe an atypical presentation of an aggressive large B-cell lymphoma mimicking a metastatic neuroendocrine tumor at initial presentation with high somatostatin receptor expression demonstrated on the 68 Ga-DOTATATE PET/CT and a rapidly progressing course on the subsequent 18 F-FDG PET/CT.

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