Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracellular developmental timers.

M Raff1

  • 1Biology Department, University College London, London WC1E 6BT, United Kingdom.

Cold Spring Harbor Symposia on Quantitative Biology
|April 19, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of perinatal outcomes between spontaneous vs. commissioned cycles in gestational carriers for single and same-sex male intended parents.

Journal of assisted reproduction and genetics·2020
Same author

Spinal cord stimulation for the management of pain: Recommendations for best clinical practice.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2013
Same author

Clinical practice guidelines for management of neuropathic pain: expert panel recommendations for South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2012
Same author

The mystery of intracellular developmental programmes and timers.

Biochemical Society transactions·2006
Same author

Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Timing cell-cycle exit and differentiation in oligodendrocyte development.

Novartis Foundation symposium·2001
Same journal

Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Small RNA Function in Plants: From Chromatin to the Next Generation.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

U1 snRNP Telescripting Roles in Transcription and Its Mechanism.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Biophysical Properties of HP1-Mediated Heterochromatin.

Cold Spring Harbor symposia on quantitative biology·2020
See all related articles

Animal development timing remains unclear. This study reviews intracellular timers controlling when oligodendrocyte precursor cells (OPCs) stop dividing and differentiate, offering insights into developmental programs.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Neuroscience

Background:

  • The precise timing of developmental events in animals is poorly understood.
  • Vertebrate precursor cells have a limited number of divisions before terminal differentiation, but the controlling mechanisms are unknown.
  • Intracellular timers are increasingly recognized as crucial for regulating cell division and differentiation timing.

Purpose of the Study:

  • To review the role of intracellular timers in controlling cell division and differentiation.
  • To explore cell-intrinsic developmental programs that govern precursor cell fate.
  • To present findings on rodent oligodendrocyte precursor cells (OPCs) as a model system.

Main Methods:

  • Review of existing research on intracellular timers and developmental programs.

Related Experiment Videos

  • Focus on oligodendrocyte precursor cells (OPCs) in rodents.
  • Analysis of cell-intrinsic mechanisms regulating cell cycle exit and differentiation.

    • Main Results:

    • Intracellular timers are key regulators of cell division limits.
    • Cell-intrinsic developmental programs dictate the timing of precursor cell differentiation.
    • Rodent OPCs exhibit defined intracellular programs controlling their cell cycle exit.

    Conclusions:

    • Intracellular timers are fundamental to controlling the timing of cell differentiation in development.
    • Understanding these timers in OPCs provides a model for broader developmental processes.
    • Further research into cell-intrinsic programs is essential for deciphering developmental timing.