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Effect of the third-strand length on the formation of DNA triple helix
N Sugimoto1, Y Shintani, M Sasaki
1Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
The triple-helix formation of octadeoxyribonucleotides, (dA)8 and (dT)8, and a shorter oligonucleotide, (dT)n (n; 4, 5, 6, or 7) has been studied by UV and CD measurements. The results showed that the third strand, (dT)5, (dT)6, or (dT)7 can bind to the double helix of (dA)8.(dT)8 at 50 mmol dm-3 MgCl2 though (dT)4 can not bind at the same concentration of the salt.